Tumor-targeted delivery of biologically active TRAIL protein
نویسندگان
چکیده
منابع مشابه
Nanoparticles for Targeted Delivery of Active Agents against Tumor Cells
Copyright © 2012 Rassoul Dinarvand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cancer therapy may still be considered as one of the most challenging issues in pharmaceutical sciences. Various new technologies and molecu...
متن کاملEnhancement of antitumor properties of TRAIL by targeted delivery to the tumor neovasculature.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent with tumor-selective apoptotic activity. TRAIL plays a role in the innate and adaptive immune response and autoimmune disease and may also be involved in hepatic cell death and inflammation. For these reasons, chronic exposure to TRAIL may have deleterious side effects in patients as a cancer therape...
متن کاملMultifunctional MIL-S─CUR@FC nanoparticles: a targeted theranostic agent for magnetic resonance imaging and tumor targeted delivery of curcumin
Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring. Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...
متن کاملSynergistic Effect of Expressed miR-128 and Puma protein on Targeted Induction of Tumor Cell Apoptosis
Background: Puma is a highly robust pro-apoptotic protein. The protein becomes activated by p53 ensuing beyond-repair DNA damage. Downregulation of SIRT 1, by miR-128, elevates activated p53 that foment Puma indirectly. Objectives: In the present study, we used two-expression Adeno-Associated Virus (AAV) system for co-expression of miR-128 and Puma in order to evaluate apoptotic response; both ...
متن کاملNanodiamonds as Carriers for Address Delivery of Biologically Active Substances
Surface of detonation nanodiamonds was functionalized for the covalent attachment of immunoglobulin, and simultaneously bovine serum albumin and Rabbit Anti-Mouse Antibody. The nanodiamond-IgG(I125) and RAM-nanodiamond-BSA(I125) complexes are stable in blood serum and the immobilized proteins retain their biological activity. It was shown that the RAM-nanodiamond-BSA(I125) complex is able to bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2010
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2009.76